TAGMASS

Developments of Specific MS Imaging and MS Immunoassays
TAGMASS & ATAMS Projects

TAGMASS project

Imaging of various targets
  1. -Antigens using tagged antibodies
  2. -Antigens using tagged aptamers
  3. -mRNA using tagged oligonucleotides
  4. -Oligosaccharides using tagged leptins

ATAMS project aims consists in the development of a multiplex based on the TAG-MASS ™ technology. This novel generation is highly sensitive technology allowing to detected biomarkers in fluids at atmol range for early diagnoses of several clinical pathologies. ATAMS (project will thus be based on the originally US patent developed by PRISM ) with a novel Tag synthesis created on click chemistry for a more rapid and cheaper production for kits production. Based on this novel generation of UTP-tagged mass, ATAMS can be used in clinics either for biomarkers titration in fluids or for pathogens identification.

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Patents

  • WO2007/000669 A2 Use of Conjugates with Linkers Cleavable by Photodissociation or Fragmentation For Mass Spectrometry Analysis of Tissue Sections Inventors: I. Fournier, R. Lemaire, M. Dechamps,I. Rudlof, M. Lemaitre, G. Proess, J.C. Tabet, M. Salzet
    Applicants: CNRS - Université Lille 1 - Eurogentec SA
    Download Patent Document

  • EP 2 322 921 A1 DNP Conjugated to a Peptide via a UV Cleavable Linker
    Inventors: I. Fournier, R. Lemaire, M. Dechamps,I. Rudlof, M. Lemaitre, G. Proess, J.C. Tabet, M. Salzet
    Applicants: CNRS - Université Lille 1 - Eurogentec SA

    Download Patent Document

    Publications
  • R. Lemaire, J. Stauber, M. Wisztorski, C. Van Camp, A. Desmons, M. Deschamps, G. Proess, I. Rudlof, A. S. Woods, R. Day, M. Salzet, I. Fournier
    J. Prot. Res. (2007) 6, 2057-2067
    TAG-MASS: Specific Molecular Imaging of Transcriptome and Proteome by Mass Spectrometry Based on Photocleavable Tag
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    Download Supplementary Information

  • Stauber J., El Ayed M., Wisztorski M., Day R., Fournier I., Salzet M.
    Anal Chem. (2009) 81(22), 9512-21
    Polymerase chain reaction and immunoassay—matrix assisted laser desorption mass spectrometry using tag-mass technology: new tools to break down quantification limits and multiplexes
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  • Gagnon H, Franck J, Wisztorski M, Day R, Fournier I, Salzet M.
    Prog Histochem Cytochem. 2012; 47(3): 133-74
    Targeted mass spectrometry imaging: specific targeting mass spectrometry imaging technologies from history to perspective
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